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Certification Provider:	USMLE
Exam Code / Number:	USMLE
Exam Name:	United States Medical Licensing Examination
Exam Questions:	400
Last Updated:	Aug 17, 2026
Corresponding Certification:	USMLE certification

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USMLE USMLE Exam Syllabus Topics:

Topic	Details
Topic 1	Adaptive behavioral responses to stress and illness Biochemistry and molecular biology
Topic 2	Deficiency of phagocytic cells and natural killer cells Adverse effects of drugs on the nervous system
Topic 3	Adverse effects of drugs on the hematologic and lymphoreticular systems Disorders associated with immunodeficiency
Topic 4	Deficiency primarily of humoral immunity Immunologic and inflammatory disorders
Topic 5	Cranial and peripheral nerve disorders Cellular basis of the immune response and immunologic mediators

Reference: http://www.usmle.org/step-1/#question-formats

USMLE exam is a critical step for medical graduates who want to practice medicine in the United States. USMLE exam evaluates a candidate’s medical knowledge, skills, and abilities, and helps to ensure that physicians are qualified and competent to practice medicine in the US. USMLE exam is divided into three parts, each focusing on a different area of medical knowledge and skills, and is considered one of the most challenging medical certification exams in the world. Passing the USMLE exam is a significant achievement for medical graduates and is essential for pursuing a successful career in medicine.

USMLE is administered by the National Board of Medical Examiners (NBME) and the Federation of State Medical Boards (FSMB). USMLE exam is broken down into three steps, with Step 1 and Step 2 being taken during medical school, and Step 3 being taken after graduation. Each step of the exam focuses on different aspects of medical knowledge and clinical skills.

The first step of the USMLE exam assesses the candidate's ability to apply their basic science knowledge to clinical medicine. This step is taken after the second year of medical school and consists of multiple-choice questions. The second step of the exam assesses the candidate's ability to apply their medical knowledge to patient care. It is usually taken during the fourth year of medical school or during the first year of residency training. This step consists of multiple-choice questions and clinical simulations. The third step of the exam assesses the candidate's ability to apply their medical knowledge to patient care in an unsupervised setting. It is taken after the candidate has completed their residency training.

Step 1 of the USMLE (United States Medical Licensing Examination) is the first part of the United States Medical Licensing Examination. It is open to medical school student and graduates to assess their ability to apply important concepts fundamental to the practice of medicine. While American medical students usually take USMLE Step 1 at the end of the second year of medical school, all graduates of foreign medical schools must take this exam is they intend to practice medicine in the United States.