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MRCPUK Endocrinology and Diabetes (Specialty Certificate Examination) Sample Questions:
1. A 32-year-old woman presented at 34 weeks of pregnancy, after an episode of vaginal bleeding. Gestational diabetes had been diagnosed at 28 weeks and insulin was started at 29 weeks. Her pre-pregnancy body mass index was 32 kg/m2 (18-25) and there was no family history of diabetes. She was treated with betamethasone 12 mg over 2 days. She was taking 60 units of insulin subcutaneously daily (40 units prandial in three divided doses, and 20 units intermediate-acting insulin), which had been unchanged for 3 weeks.
On examination, she was apyrexial, her pulse was 96 beats per minute and her blood pressure was 124/74 mmHg. Urinalysis showed blood 1+, protein 1+, glucose 2+, ketones 3+.
Investigations:
serum sodium134 mmol/L (137-144)
serum potassium3.8 mmol/L (3.5-4.9)
serum chloride105 mmol/L (95-107) serum urea5.0 mmol/L (2.5-7.0) serum creatinine90 umol/L (60-110) random plasma glucose7.2 mmol/L
What is the most appropriate next step in management?
A) measure venous bicarbonate
B) increase subcutaneous insulin doses by 2-4 units
C) discharge and monitor blood glucose at home
D) start intravenous insulin
E) continue to monitor blood glucose in hospital
2. A 56-year-old man with a 5-year history of type 2 diabetes mellitus was worried about developing a foot ulcer.
Which clinical feature, if present, best predicts the development of a foot ulcer in a patient with diabetes?
A) history of a previous foot ulcer
B) inability to perform own foot care
C) absent sensation to a monofilament
D) absent foot pulses
E) vibration perception threshold >25v
3. A 47-year-old man presented with a 2-month history of polyuria and polydipsia. He awoke six times most nights to pass copious volumes of urine despite not drinking any fluid for 4 hours before going to bed.
Investigations:
MR scan of pituitary fossasee image
A water deprivation test confirmed the diagnosis of cranial diabetes insipidus.
What is the most likely underlying diagnosis?
A) chordoma
B) meningioma
C) craniopharyngioma
D) microadenoma
E) Langerhans' histiocytosis
4. An 18-year-old man was referred with muscle weakness and cramps. His blood pressure was 108/60 mmHg.
Investigations:
serum sodium143 mmol/L (137-144) serum potassium2.4 mmol/L (3.5-4.9) serum bicarbonate32 mmol/L (20-28) serum magnesium0.96 mmol/L (0.75-1.05)
24-h urinary calcium3.6 mmol (2.5-7.5) 24-h urinary magnesium4.2 mmol (2.5-8.0)
plasma renin activity (after 30 min supine)6.4 pmol/mL/h (1.1-2.7) plasma aldosterone (after 30 min supine)680 pmol/L (135-400)
What is the most likely diagnosis?
A) Gitelman's syndrome
B) renal tubular acidosis
C) syndrome of apparent mineralocorticoid excess
D) Bartter's syndrome
E) Liddle's syndrome
5. A 71-year-old man was brought to the emergency department in a collapsed state. He was
unable to give a history. Records showed that he had ischaemic heart disease and had undergone coronary bypass grafting 2 years previously. He was taking bendroflumethiazide 2.5 mg daily and simvastatin 40 mg at bedtime.
On examination he was unwell. His pulse was 128 beats per minute and his blood pressure was 108/60 mmHg. Oxygen saturation was 96% (94-98) breathing air.
An ECG showed Q waves in leads II, III, and aVF.
Investigations:
serum sodium164 mmol/L (137-144)
serum potassium5.4 mmol/L (3.5-4.9)
serum bicarbonate19 mmol/L (20-28)
serum urea15.2 mmol/L (2.5-7.0)
serum creatinine145 umol/L (60-110)
random plasma glucose81.2 mmol/L
What is the most appropriate fluid replacement?
A) compound sodium lactate intravenous infusion
B) sodium chloride 0.45%
C) sodium chloride 0.9%
D) sodium chloride 0.9% and glucose 5%
E) colloid
Solutions:
| Question # 1 Answer: A | Question # 2 Answer: A | Question # 3 Answer: E | Question # 4 Answer: D | Question # 5 Answer: C |
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